Hepcidin Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90629-50, BS90629-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P81172(Human)

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC

All Applications: WB:1:500-1:1,000
IHC:1:50-1:200

Background: Hepcidin, also known as HAMP, HEPC, LEAP1 or HFE2B, is an 84 amino acid secreted protein that regulates iron-related signaling events. Highly expressed in liver with lower expression in heart, brain, lung, prostate and thyroid, hepcidin is thought to maintain iron homeostasis and, in conjunction with the HFE protein (a protein that is defective in hereditary hemochromatosis), may mediate both iron storage in macrophages and intestinal iron absorption. Additionally, hepcidin has strong antimicrobial activity against gram-positive and gram-negative bacteria, as well as certain yeast strains, suggesting that hepcidin may play a crucial role in staving off bacterial infections. Defects in the gene encoding hepcidin are the cause of hemochromatosis type 2B (also known as juvenile hemochromatosis), an early-onset autosomal recessive disorder that results in severe iron overload and is characterized by hepatic fibrosis, hypogonadotrophic hypogonadism and cardiomyopathy.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Hepcidin polyclonal antibody detects endogenous levels of Hepcidin protein.

Bioworld Molecular Weight: 3 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti- Hepcidin antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded rat heart tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.

Alternative Name: LEAP-1, PLTR, Hepc25, Hepc20, HAMP, Hamp, HEPC, HEPC, Hepc20, Hepc25, Hepcidin-20, HFE2B, LEAP-1, LEAP1, Liver-expressed antimicrobial peptide 1, PLTR, Putative liver tumor regressor,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified