HtrA2/Omi Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90676-50, BS90676-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O43464(Human) Q9JIY5(Mouse) Unigene:107325(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP,

All Applications: WB:1:1,000-1:2,000
IHC:1:50-1:200

Background: The human homolog of the E. Coli htrA gene product, HtrA, is identified in osteoarthritic cartilage and is repressed in SV40-transformed fibroblast. The gene encoding HtrA protein is highly conserved among mammalian species and belongs to the serine protease family. The HtrA protein contains an IGF-binding domain and exhibits endoproteolytic activity, including autocatalytic cleavage. HtrA is a secreted protein that is expressed in heterologous systems. HtrA plays a role in the degradation of denatured proteins and cell growth regulation. Human HtrA2 (also designated Omi), a novel member of the HtrA serine protease family, is highly homologous to HtrA (also known as L56 and HtrA1). HtrA2 is a ubiquitously expressed nuclear protease that is capable of autoproteolysis. The HtrA2 protein exists as two polypeptides and as an alternatively spliced form called D-Omi, which is predominately expressed in the kidney, colon and thyroid. Due to a modified PDZ domain, D-Omi does not interact with the known partner of HtrA2, the Mxi2 protein. Like HtrA, HtrA2 is involved in the degradation aberrantly folded proteins during conditions of cellular stress, suggesting that it may possess a chaperone-like role under normal conditions.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: HtrA2/Omi polyclonal antibody detects endogenous levels of HtrA2/Omi protein.

Bioworld Molecular Weight: 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of HtrA2 on 293 cell lysates using anti-HtrA2 antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-HtrA2 antibody. Counter stained with hematoxylin.

Alternative Name: HtrA2, HTRA2, OMI, PRSS25, High temperature requirement protein A2, HTRA 2, HtrA like serine protease, HtrA serine peptidase 2, HtrA, E. coli, homolog of, 2, HtrA2, HTRA2, mitochondrial, Omi stress regulated endoprotease, Omi stress-regulated endoprotease, PARK 13, PARK13, Protease serine 25, PRSS 25, PRSS25, Serine protease 25, Serine protease HTRA2, Serine protease HTRA2 mitochondrial, Serine protease htra2 mitochondrial precursor, Serine protease omi, Serine proteinase OMI,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified