IGFBP2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90689-50, BS90689-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P18065(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

All Applications: WB:1:500-1:2,000
IHC:1:50-1:200

Background: The Insulin-like growth factor-binding proteins (IGFBPs), a family of homologous proteins that have co-evolved with the IGFs, serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, and their concentration and distribution in the extracellular environment. The IGFBPs also appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP1 is negatively regulated by Insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. IGFBP2, which may function as a chaperone, escorting IGFs to their target tissues, is expressed in several human tissues including fetal eye and fetal brain.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: IGFBP2 polyclonal antibody detects endogenous levels of IGFBP2 protein.

Bioworld Molecular Weight: 35 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of IGFBP2 on Human serum (1) and NCCIT (2) lysates using anti-IGFBP2 antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-IGFBP2 antibody. Counter stained with hematoxylin.

Alternative Name: IBP-2, IGF-binding protein 2, IGFBP-2, IGFBP2, BP2, IBP2, BP 2, BP2, IBP 2, IBP-2, IBP2, IBP2, IGF binding protein 2, IGF BP53, IGF-binding protein 2, IGFBP 2, IGFBP-2, IGFBP2, IGFBP53, Insulin like growth factor binding protein 2 36kDa, Insulin like growth factor binding protein 2, Insulin like growth factor-binding protein 2 precursor, Insulin-like growth factor-binding protein 2,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified