Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.

Product information

CAS Number: 544-31-0

Molecular Weight: 299.49

Formula: C18H37NO2

Chemical Name: N-(2-hydroxyethyl)hexadecanamide

Smiles: CCCCCCCCCCCCCCCC(=O)NCCO

InChiKey: HXYVTAGFYLMHSO-UHFFFAOYSA-N

InChi: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 2.6 mg/mL (8.68 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Palmitoylethanolamide (Palmidrol) itself does not stimulate interferon production in mice treated per os or intravenously. But repeated application of this drug per os induces a macrophage activation, reflected by enhanced interferon production in vitro. When the interferon stimulation is delayed until 4 to 10 days after the first dose of Palmitoylethanolamide, interferon response to ds-RNA is slightly increased. After this phase of enhanced activity a decreased production of interferon is observed. Palmitoylethanolamide is not significantly effective in protecting mice from lethal dose of EMC virus. Application of this drug has an inhibitory effect on the toxicity of ds-RNA. A possible explanation of the mechanism by which Palmitoylethanolamide decreased the toxicity of virus in the organism is discussed.

Products are for research use only. Not for human use.