PTPα (phospho Tyr798) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6938-50, ES6938-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],

Alternate Name: PTPRA; PTPA; PTPRL2; Receptor-type tyrosine-protein phosphatase alpha; Protein-tyrosine phosphatase alpha; R-PTP-alpha

Source: Rabbit

Applications: WB; ELISA; IHC

Dilution: WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Reactivity: Human; Mouse; Rat; Monkey

Immunogen: The antiserum was produced against synthesized peptide derived from human PTPRA around the phosphorylation site of Tyr798. AA range:753-802

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100 90kD

Human Gene ID: 5786

Human SWISS Prot NO: P18433

Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Localizes to focal adhesion sites following integrin engagement.

Research Use Only