HMGCS1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-13295-60, E-AB-13295-120, E-AB-13295-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: HMGCS1

Target Synonym: 3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble); 3-hydroxy-3-methylglutaryl coenzyme A synthase; cytoplasmic; EC 2.3.3.10; HMCS1; HMG CoA synthase; HMG-CoA synthase; HMGCS; HMGCS1; Hydroxymethylglutaryl CoA synthase; cytoplasmic; Hydroxymethylglutaryl-CoA synthase; MGC90332

Research Areas: Cancer, Cardiovascular, Metabolism, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q01581

Background: HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.

Concentration: 0.4 mg/mL

Immunogen: Synthetic peptide of human HMGCS1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Calculated MW: 57kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only