NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells.

Product information

CAS Number: 1006028-37-0

Molecular Weight: 1180.74

Formula: C47H44N6Na4O17P4

Chemical Name: tetrasodium (Z)-N-[2,4-bis(phosphonomethyl)phenyl]-3-[(Z)-[(3-{[(Z)-{3-[(Z)-{5-[(Z)-[2,4-bis(phosphonomethyl)phenyl]carboximidato]-2-methylphenyl}carboximidato]phenyl}-C-hydroxycarbonimidoyl]amino}phenyl)(oxido)methylidene]amino]-4-methylbenzene-1-carboximidate

Smiles: [Na+].[Na+].[Na+].[Na+].CC1C=CC(=CC=1/N=C(\[O-])/C1=CC(=CC=C1)N/C(/O)=N/C1C=C(C=CC=1)/C(/[O-])=N/C1C=C(C=CC=1C)/C(/[O-])=N/C1C=CC(CP(O)(O)=O)=CC=1CP(O)(O)=O)/C(/[O-])=N/C1C=CC(CP(O)(O)=O)=CC=1CP(O)(O)=O

InChiKey: GSMUPMANKNAMAS-UHFFFAOYSA-J

InChi: InChI=1S/C47H48N6O17P4.4Na/c1-27-9-13-33(45(56)50-39-15-11-29(23-71(59,60)61)17-35(39)25-73(65,66)67)21-41(27)52-43(54)31-5-3-7-37(19-31)48-47(58)49-38-8-4-6-32(20-38)44(55)53-42-22-34(14-10-28(42)2)46(57)51-40-16-12-30(24-72(62,63)64)18-36(40)26-74(68,69)70;;;;/h3-22H,23-26H2,1-2H3,(H,50,56)(H,51,57)(H,52,54)(H,53,55)(H2,48,49,58)(H2,59,60,61)(H2,62,63,64)(H2,65,66,67)(H2,68,69,70);;;;/q;4*+1/p-4

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

NF546 is relatively selective for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6, P2Y12, P2X1, P2X2, and P2X2-X3. NF546 (100 μM; 24 hours) is equi-efficacious in stimulating TSP-1 release and inhibiting the LPS-induced release of IL-12p70 in human monocyte-derived dendritic cells.

Products are for research use only. Not for human use.