AH 11110 hydrochloride is a selective antagonist of α1B-adrenoceptor . α1B-adrenoceptor (α1B-AR) belongs to α1- adrenergic receptors, which include three subtypes α1A, α1B and α1D and play an important role in regulating cell growth and proliferation. AH 11110 hydrochloride is a selective α1B-AR antagonist. AH11110A inhibited cloned α1B-AR with Ki value of 79.4 nM and exhibited 32- and 26-fold selectivity over α1A- and α1D-ARs, respectively . In rat vas deferens and rat perfused kidney, AH11110A exhibited affinities for α1A-AR, α1B-AR and α1D-AR with pA2 values of 6.41, 5.40-6.54 and 5.47-5.48, respectively. Also, AH11110A displayed affinity for α2-adrenoceptor in rabbit vas deferens with pA2 value of 5.44. In ligand binding studies, AH11110A exhibited affinities for native and cloned α1B-AR with pKi of 7.10-7.73. AH11110A increased contraction of rat vas deferens . In isolated spleen strips from guinea-pig, AH11110A competitively antagonized tissue contraction induced by noradrenaline in a concentration-dependent way .

Product information

CAS Number: 179388-65-9

Molecular Weight: 374.90

Formula: C21H27ClN2O2

Chemical Name: (2S)-1-{[1,1'-biphenyl]-2-yloxy}-4-imino-4-(piperidin-1-yl)butan-2-ol hydrochloride

Smiles: Cl.N=C(C[C@H](O)COC1=CC=CC=C1C1C=CC=CC=1)N1CCCCC1

InChiKey: WWHGFIXWBLHHQB-FERBBOLQSA-N

InChi: InChI=1S/C21H26N2O2.ClH/c22-21(23-13-7-2-8-14-23)15-18(24)16-25-20-12-6-5-11-19(20)17-9-3-1-4-10-17;/h1,3-6,9-12,18,22,24H,2,7-8,13-16H2;1H/t18-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

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