BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively .

Product information

CAS Number: 186185-03-5

Molecular Weight: 680.79

Formula: C36H48N4O9

Chemical Name: (2S)-2-hydroxypropanoic acid; 3,5-dimethyl 4-(3-{[(Z)-{3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}-C-hydroxycarbonimidoyl]amino}phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Smiles: C[C@H](O)C(O)=O.CC1NC(C)=C(C(C2=CC(=CC=C2)N/C(/O)=N/CCCN2CCC(CC2)C2=CC(=CC=C2)OC)C=1C(=O)OC)C(=O)OC

InChiKey: BYHJIPSVXAFCDI-WNQIDUERSA-N

InChi: InChI=1S/C33H42N4O6.C3H6O3/c1-21-28(31(38)42-4)30(29(22(2)35-21)32(39)43-5)25-10-6-11-26(19-25)36-33(40)34-15-8-16-37-17-13-23(14-18-37)24-9-7-12-27(20-24)41-3;1-2(4)3(5)6/h6-7,9-12,19-20,23,30,35H,8,13-18H2,1-5H3,(H2,34,36,40);2,4H,1H3,(H,5,6)/t;2-/m.0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (169.29 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.