FLX925, also known as AMG-925, is a potent and selective type 1 inhibitor of FLT3 that retains its cellular potency against clinically relevant secondary resistance mutations in FLT3 occurring with quizartinib or sorafenib treatment (FLX925 IC50: MOLM13ITD, 15 nM; MOLM13ITD/D835, 28 nM; MV4-11ITD, 16 nM; MV4-11ITD/D835, 19 nM; MV4-11ITD/N841, 16 nM; MV4-11ITD/F691, 73 nM).

Product information

CAS Number: 1401033-86-0

Molecular Weight: 471.55

Formula: C26H29N7O2

Synonym:

AMG-925

AMG925

Chemical Name: 2-hydroxy-1-(2-{[8-(4-methylcyclohexyl)-4,6,8,11-tetraazatricyclo[7.4.0.0²,⁷]trideca-1(9),2,4,6,10,12-hexaen-5-yl]amino}-5,6,7,8-tetrahydro-1,6-naphthyridin-6-yl)ethan-1-one

Smiles: CC1CCC(CC1)N1C2=NC(NC3=CC=C4CN(CCC4=N3)C(=O)CO)=NC=C2C2=CC=NC=C12

InChiKey: BBUVDDPUURMFOX-UHFFFAOYSA-N

InChi: InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.